The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells
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چکیده
منابع مشابه
linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis.
Recently, researchers have uncovered the presence of many long noncoding RNAs (lncRNAs) in embryonic stem cells and believe they are important regulators of the differentiation process. However, there are only a few examples explicitly linking lncRNA activity to transcriptional regulation. Here, we used transcript counting and spatial localization to characterize a lncRNA (dubbed linc-HOXA1) lo...
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Differences in Gene Expression between Wild Type and Hoxa1 Knockout Embryonic Stem Cells after Retinoic Acid Treatment or LIF Removal* Eduardo Martinez-Ceballos¶, Pierre Chambon‡, and Lorraine J. Gudas¶§ From the ¶Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Ave., New York, NY 10021. and ‡Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/...
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Congenital heart disease is one of the most common human birth defects, yet many genes and pathways regulating heart development remain unknown. A recent study in humans revealed that mutations in a single Hox gene, HOXA1 (Athabascan Brainstem Dysgenesis Syndrome, Bosley-Salih-Alorainy Syndrome), can cause severe cardiovascular malformations, some of which are lethal without surgical interventi...
متن کاملHoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere.
Loss of Hoxa1 function results in severe defects of the brainstem, inner ear, and cranial ganglia in humans and mice as well as cardiovascular abnormalities in humans. Because Hoxa1 is expressed very transiently during an early embryonic stage, it has been difficult to determine whether Hoxa1 plays a direct role in the precursors of the affected organs or if all defects result from indirect eff...
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Hox transcription factors play critical roles during early vertebrate development. Previous studies have revealed an overlapping function of Hoxa1 and Hoxb1 during specification of the rhombomeres from which neural crest cells emerge. A recent study on Hoxa1 mutant mice documented its function during cardiovascular development, however, the role of Hoxb1 is still unclear. Here we show using sin...
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ژورنال
عنوان ژورنال: Journal of Cellular Biochemistry
سال: 2009
ISSN: 0730-2312,1097-4644
DOI: 10.1002/jcb.22023